Lactoferrin and CDI

Hae Mi Lee, Seungok Lee, Bo-In Lee, Dong Wook Jekarl, Joo-Yong Song, Hye-Jung Choi, Bong Koo Kang, Eun Joo Im, Joon Sung Kim, Jong In Kim, Byung-Wook Kim, and Hwang Choi
Clinical Significance of Fecal Lactoferrin and Multiplex Polymerase Chain Reaction in Patients with Acute Diarrhea
2015. Gut Liver. 9(5): 636-640

F. Barbut, C. Gouot, N. Lapidus, L. Suzon, R. Syed-Zaidi, V. Lalande, C. Eckert
Faecal lactoferrin and calprotectin in patients with Clostridium difficile infection: a case-control study
2017. Eur J Clin Microbial Infect Dis. 36(12):2423-2430

L. Archibald-Pannone, J. Sevilleja, R. Guerrant.
Diarrhea, Clostridium difficile, and intestinal inflammation in residents of a long-term care facility. 
2010. J Am Med Dir Assoc. 11 (4): 263-7

J. Boone, L. Archibald-Pannone, K. Wickham, R. Carman, R. Guerrant, C. Franck, D. Lyerly.
Ribotype 027 Clostridium difficileinfections with measurable stool toxin have increased lactoferrin and are associated with a higher mortality. 
2014. Eur J Clin Microbial Infect Dis. 33 (6) 1045-51.

J. Boone, J. DiPersio, M. Tan, S. Salstrom, K. Wickham, R. Carman, H. Totty, R. Albert, D. Lyerly.
Elevated lactoferrin is associated with moderate to severe Clostridium difficiledisease, stool toxin, and 027 infections. 
2013. Eur J Clin Microbial Infect Dis. 32: 1517-1523

P. LaSala, T. Eckhmimi, A. Hill, I. Farooqi, P. Perrotta.
Quantitative fecal lactoferrin in toxin-positive and toxin-negative Clostridium difficile specimens. 
2012. J Clin Microbial. DOI: 10.1128/JCM.02735-12

M. Wren, M. Sivapalan, R. Kinson, N. Shetty.
Laboratory diagnosis of Clostridium difficile infection. An evaluation of tests for faecal toxin, glutamate dehydrogenase, lactoferrin and toxigenic culture in the diagnostics laboratory. 
2008. Br J Biomed Sci. 661 (1): 1-5

S. Pawlowski, L. Archibald-Pannone, R. Carman, C. Alcantara-Warren, D. Lyerly, C. Genheimer, D. Gerding, R. Guerrant.
Elevated levels of intestinal inflammation in Clostridium difficileinfection associated with fluoroquinolone-resistant C. difficile
2009. J Hosp Infect. 73 (2): 185-187

R. El Feghaly, J. Stauber, E. Deych, C. Gonzalez, P. Tarr, D. Haslam.
Markers of intestinal inflammation, not bacterial burden, correlate with clinical outcomes in Clostridium difficileinfection. 
2013. Clinical Infectious Diseases 56 (12): 1713-2


Lactoferrin and IBS/IBD

C.A. Lamb, J.C. Mansfield
Measurement of faecal calprotectin and lactoferrin in inflammatory bowel disease
2011. Gastroenterology. 2011;2:13-18

Wang Y, Pei F, Wang X, Sun Z, Hu C, Dou H.
Diagnostic accuracy of fecal lactoferrin for inflammatory bowel disease: a meta-analysis
2015. Int. J. Clin. Exp. Pathol. 2015;8(10):12319-31.

Xing-lu Zhou, Wen Xu, Xiao-xiao Tang, Lai-sheng Luo, Jiang-feng Tu, Chen-jing Zhang, Xiang Xu, Qin-dong Wu, and Wen-sheng Pan
Fecal lactoferrin in discriminating inflammatory bowel disease from Irritable bowel syndrome: a diagnostic meta-analysis
2014. BMC Gastroenterol 14: 121

J. Däbritz, J. Musci, D. Foell.
Diagnostic utility of faecal biomarkers in patients with irritable bowel syndrome. 
2014. World Journal of Gastroenterol 20:2. 363-375.

R. Sidhu, P. Wilson, A. Wright, C. Yau, F. D’Cruz, L. Foye, S. Morley, A. Lobo, M. Mcalindon, D. Sanders.
Faecal lactoferrin—a novel test to differentiate between the irritable and inflamed bowel? 
2010. Alimentary Pharmacology & Therapeutics 31. 1365-1370

T. Walker, M. Land, A. Kartashov, T. Saslowsky, D. Lyerly, J. Bonne, P. Rufo.
Fecal lactoferrin is a sensitive and specific marker of disease activity in children and young adults with inflammatory bowel disease. (Subscription required to view full text) 
2007. J Pediatr Gastroenterol Nutr 44:4. 414-422

M. Parsi, B. Shen, J. Achkar, F. Remzi, J. Goldblum, J. Boone, D. Lin, J. Connor, V. Fazio, B. Lashner.
Fecal lactoferrin for diagnosis of symptomatic patients with ileal pouch- anal anastomosis. 
2004. Gastroenterology 126. 1280-1286.

S. Kane, W. Sandborn, P. Rufo, A. Zholudev, J. Boone, D. Lyerly, M. Camilleri, S. Hanauer.
Fecal lactoferrin is a sensitive and specific marker in identifying intestinal inflammation. (Purchase required to view full text) 
2003. Am J Gastroenterol 98:6. 1309-1314.

G. Van Assch, S. Hanauer
Fecal biomarkers for the diagnosis and management of inflammatory bowel disease. (Purchase required to view full text)
2011. Gastro and Hep 7:6. 396-398.

B. Abraham, S. Kane.
Fecal markers: calprotectin and lactoferrin. (Purchase required to view full text) 
2013. Gastroenterol Clin N Am. 41. 483-495.