Innovations in the Diagnosis of Intestinal Diseases
Techlab Enteric DiagnosticsProducts

INTESTINAL INFLAMMATION

Selected Poster Presentations

Evaluation of Fecal Lactoferrin, CRP and Clinical Activity Indices for Assessing the Presence of Intestinal Inflammation in IBD and IBS Patients Classified by Ileocolonoscopy
Jost Langhorst(1), James Boone(2), Adreas Rueffer(3), Andreas Michalsen(1), and Gustav Dobos(1)
1. Department of Internal and Integrative Medicine V, Kliniken-Essen-Mitte, University of Duisburg-Essen, Germany, 2. TECHLAB®, Inc., Blacksburg, Virginia USA and 3. Labor L+S/Enterosan, Bad Bocklet-Grossenbrach, Germany

Evaluation of Fecal and Serum Anti-Saccharomyces cerevisiae Antibodies (ASCA) as an Aid in the Diagnosis of Crohn's Disease
Jost Langhorst(1), James Boone(2), Adreas Rueffer(3), Andreas Michalsen(1), and Gustav Dobos(1)
1. Department of Internal and Integrative Medicine V, Kliniken-Essen-Mitte, University of Duisburg-Essen, Germany, 2. TECHLAB®, Inc., Blacksburg, Virginia USA and 3. Labor L+S/Enterosan, Bad Bocklet-Grossenbrach, Germany

Post operative Crohn’s disease: The role of faecal lactoferrin in detecting clinical relapse after ileocaecal resection and measurement of faecal ASCA
M. K. Mohiuddin, J. Gicquel, J. Robson, C. Todhunter, J. M. Hanson, J. C. Mansfield
1. Royal Victoria Infirmary, Newcastle, 2. Freeman Hospital, Newcastle
Presented at the annual conference of the Association of Surgeons of Great Britain and Ireland 2007, April 18 - 20, Manchester, UK

A Cross-Sectional Study of the Correlation Between CRP, Interleukin-6 (IL-6), Fecal Lactoferrin and Fecal Calprotectin in Patients with Active Crohn's Disease
Jones J(1), Panaccione R(1), ChenPeterson S(2), McConnell(2), Baudhuin L(3), Hanson K(4), Feagan B(5), Harmsen W(6), Loftus E(4), Zinsmeister A(6), Helou A(4), and Sandborn W(4)
4. Divisions of Gastroenterology and Hepatology, 3. Division of Clinical and Molecular Genetics, 2. Division of Laboratory Medicine and 6. Division of Biostatistics at Mayo Clinic College of Medicine, Rochester Minnesota, USA; 1. University of Calgary Alberta, Alberta, Canada; 5. University of Western Ontario, Lindon, Ontario, Canada.
Presented at Digestive Disease Week 2007, May 19-24, Washington, D.C., USA

Evaluation of Fecal Lactoferrin, CRP and Clinical Activity Indices for Assessing the Presence of Intestinal Inflammation in IBD and IBS Patients Classified by Ileocolonoscopy
Jost Langhorst(1), James Boone(2), Andreas Rueffer(3), Andreas Michalsen(1), and Gustav Dobos(1)
1. Department of Internal and Integrative Medicine V, Kliniken-Essen-Mitte, University of Duisburg-Essen, Germany, 2. TECHLAB®, Inc., Blacksburg, Virginia, USA and 3. Labor L+S/Enterosan, Bad Bocklet-Grossenbrach, Germany
Presented at Digestive Disease Week 2007, May 19-24, Washington, D.C., USA

A Rapid Non Invasive Test for the Qualitative Detection of Elevated Faecal Lactoferrin in Ileal Pouch Patients with Inflammation
S. Gonsalves, D. Thekkinkattil, M. Lim, P. Finan, P. Sagar, D. Burke
Department of Colorectal Surgery, The General Infirmary at Leeds, Leeds, United Kingdom
Presented at the annual scientific meeting of the British Society of Gastroenterology 2007, March 26 - 29, Glasgow, UK

Assessing Intestinal Inflammation Using A New Rapid in vitro Assay That Detects Lactoferrin
D.A. Whitlock, S.F. Sigmon, and J.H. Boone
TECHLAB®, Inc., Blacksburg, Virginia, USA
Presented at the American College of Gastroenterology Meeting, 2006

Fecal ASCA Measurements in the Assessment of Pediatric Patients with Crohn's Disease (CD) or Suspected Inflammatory Bowel Disease (IBD)
Vivian Tang, B.A.(1); Thomas R. Walker, M.D.(1); Tracee Saslowsky, M.S.N.(1); Kimberly Ong, B.A.(1); Lori Rosenberg, M.D.(1); James Boone, M.S.(2); Krista Tygrett, B.S.(2); Paul A. Rufo, M.D., M.M.Sc(1)
1. Children's Hospital Boston, Boston, MA; 2. TECHLAB®, Inc., Blacksburg, VA
Presented at the First European Symposium on Pediatric Inflammatory Bowel Disease, November 23 - 25, 2006, Rome, Italy

Fecal Lactoferrin: Reliable Inflammatory Marker in Pediatric IBD
S. Buderus(1,2), M. J. Lentze(2), J. Boone(3)
1. Department Paediatrics, St.-Marien-Hospital, 2. Children's University Hospital, Bonn, 3. TECHLAB®, Inc., USA
Presented at the United European Gastroenterology Week 2006, October 21 - 25, Berlin, Germany

Comparison of CRP, Clinical Activity Indices and Fecal Lactoferrin with Disease Status in Ileocolonoscopy of Patients with IBD and IBS
Jost Langhorst(1), James Boone(2), Andreas Rueffer(3), Andreas Michalsen(1), and Gustav Dobos(1)
1. Department of Internal and Integrative Medicine V, Kliniken-Essen-Mitte, University of Duisburg-Essen, Germany, 2. TECHLAB®, Inc., Blacksburg, Virginia, USA and 3. Labor L+S/Enterosan, Bad Bocklet-Grossenbrach, Germany
Presented at Digestive Disease Week 2006, May 20-25, Los Angeles, CA, USA

Measurement of ASCA, Lactoferrin and Clostridium Difficile in Feces of Patients with IBD
J. H. Boone(1), M. P. Sparrow(2), C. W. Genheimer(1), D. Reddy(2), D. M. Lyerly(1), and S. V. Kane(2)
1. TECHLAB®, Inc., Blacksburg, Virginia and 2. University of Chicago Medical Center, Chicago, Illinois
Presented at the American College of Gastroenterology Meeting, November 2005, Honolulu, Hawaii, USA

Fecal Lactoferrin in Children With Gastrointestinal Symptoms
Marian Pfefferkorn, MD; James Boone*, MS; Steven Steiner, MD; Gail Waltz, RN; Sue Lee, BS; Krista Tygrett*, BS
James Whitcomb Riley Hospital for Children / Indiana University School of Medicine, Indianapolis, Indiana; *TECHLAB®, Inc., Blacksburg, Virginia
Presented at the American College of Gastroenterology Meeting, November 2005, Honolulu, Hawaii, USA

Comparison of Fecal Lactoferrin and Calprotectin Levels in Healthy Subjects
Darcy Whitlock, Robert Allen, James Boone
TECHLAB®, Inc., Blacksburg, VA, USA
Presented at the World Congress of Gastroenterology, September 10-14 2005, Montreal, Canada

Fecal Anti-Saccharomyces Cerevisiae Antibodies Are A Potentially Useful Diagnostic Test To Discriminate Crohn's Disease From Other Diarrheal Illnesses
Miles P. Sparrow MB.BS, FRACP, Sunanda Kane M.D., Deepa Reddy MB.BS and James H. Boone M.S.
Department of Gastroenterology and Nutrition, University of Chicago Medical Center, Chicago, Illinois TECHLAB®, Inc., Blacksburg, Virginia
Presented at Digestive Disease Week 2005, May 14-19, Chicago, Illinois, USA

Measurement of Fecal Lactoferrin, Anti-Saccharomyces Cerevisiae (ASCA) and Anti-Neutrophil Cytoplasmic Antigen (ANCA) Antibodies in IBD and Non-IBD Patients, and Healthy Control Subjects
James Boone, Darcy Whitlock and David Lyerly
TECHLAB®, Inc., Blacksburg Virginia
Presented at Digestive Disease Week 2005, May 14-19, Chicago, Illinois, USA

Fecal lactoferrin in newborns, infants and toddlers - Evaluation in asymptomatic children and patients with functional disorders
Stephan Buderus, Alexandra Kehl, Andreas Muller, Gesche Duker, Helma Ringelmann, P. Bartmann, Michael J. Lentze, University Children's Med. Center & St.-Marien-Hospital, Bonn, Germany;
James Boone, TECHLAB®, Inc., Blacksburg, Virginia
Presented at Digestive Disease Week 2005, May 14-19, Chicago, Illinois, USA

The Detection of Lactoferrin, ASCA and ANCA in Feces is useful for Assessing Pediatric IBD Patients
James Boone, M.S., Darcy Whitlock, M.S., Daniel Sisco, M.S., TECHLAB®, Inc., Blacksburg Virginia;
Thomas Walker, M.D. and Paul Rufo, M.D., Children's Hospital of Boston, Boston, Massachusetts.
Presented at the American College of Gastroenterology Meeting, October 2004, Kissimmee, Florida

A Comparison Among Four Neutrophil-Derived Proteins In Feces As Indicator Of Disease Activity In Ulcerative Colitis
Jost Langhorst (1), Twyla Mueller (1), James Boone (2), Sigrid Elsenbruch (3), Guenther Spahn (1), Andreas Michalsen (1), Gustav Dobos (1)
1. Department of Internal and Integrative Medicine V, Kliniken-Essen-Mitte, University of Duisburg-Essen, Germany 2. TECHLAB®, Inc., U.S.A. 3. Department of Medical Psychology, University of Duisburg-Essen, Germany
Presented at Digestive Disease Week 2004, May 15-20, New Orleans, Louisiana, USA

Serial Fecal Lactoferrin Measurements are Useful in the Interval Assessment of Patients with Active and Inactive Inflammatory Bowel Disease
Thomas R. Walker, Michelle L. Land, Tracee M. Cook, Harvard University; William Sandborn, Therese Johnson, Mayo Clinic, Rochester, MN; James Boone, David Lyerly, TECHLAB®, Inc., Blacksburg, Virginia; Paul A. Rufo, Harvard University, Boston, MA
Presented at Digestive Disease Week 2004, May 15-20, New Orleans, Louisisana, USA

Clinical Evaluation of a Lateral Flow Test for the Detection of Elevated Fecal Lactoferrin as an Indicator of Intestinal Inflammation
James Boone, Daniel Sisco, and David Lyerly, TECHLAB®, Inc., Blacksburg, VA; Thomas Walker and Paul A. Rufo, Children's Hospital of Harvard University, Boston, MA.
Presented at Digestive Disease Week 2003, May 18-21, Orlando, Florida, USA

Clinical Evaluation of the IBD-CHEK® Test for Detecting Elevated Fecal Lactoferrin as an Indicator of Intestinal Inflammation in Pediatric Patients
S. Buderus, N. Lohmann, M. J. Lentze, University Children's Medical Center, Bonn, Germany J. Boone, D. Lyerly, TECHLAB®, Inc., Blacksburg, Virginia
Presented at Digestive Disease Week 2003, May 18-21, Orlando, Florida, USA

Fecal Lactoferrin: Sensitive Marker for Monitoring Pediatric Patients with Inflammatory Bowel Diesase (IBD)
S. Buderus, M.J. Lentze, University Children's Medical Center, Bonn, Germany; J. Boone, D. Lyerly, TECHLAB®, Inc., Blacksburg, Virginia
Presented at Digestive Disease Week 2002, May 19-22, San Francisco, California, USA

Fecal Anti-Saccharomyces Cerevisiae Antibodies (ASCA) - Evaluation of a New Diagnostic Test in Pediatric Patients with Inflammatory Bowel Disease
Stephan Buderus, Helma Ringelmann, Michael J. Lentze, Univ Children's Med. Center, Bonn, Germany; James Boone, David Lyerly, TECHLAB®, Inc., Blacksburg, Virginia

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